Screening Method for 122 Acidic, Neutral and Basic Drug Analytes in Plasma, Serum, Urine, or Tissue by LC-MS/MS

With the use of LC/MS/MS and full screen (QTrap methodology) the complete detection of both illicit and prescribed drugs can be accomplished easily with a simple solid phase extraction preparation. This application note shows the development of a rapid, highly sensitive qualitative method for the analysis of acidic, neutral, and basic compounds in biological fluids using Clean Screen XCEL® I solid phase extraction columns. The sample preparation is minimized while efficiently extracting a large group of representative compounds.