Screening of copolymer nanodiscs with multi-parameter stability characterization on the Prometheus Panta

Cryogenic electron microscopy (cryo-EM) has enabled atomic-level structure determination of many complex proteins that were not previously achievable with X-ray crystallography or nuclear magnetic resonance (NMR). Explore how the application of dynamic light scattering (DLS) and nano differential scanning fluorimetry (nanoDSF), provided by the Prometheus Panta, helps membrane protein structural biologists rapidly find the best copolymers for their synthetic nanodiscs, ensuring the highest atomic resolution for cryo-EM structures.