Sensitive Determination of THCCOOH in Hair to Regulatory Requirements Using Triple Quadrupole GC-MS/MS

This application note details a study in which the analytical setup for determination of THCCOOH in hair using GC-MS triple-quadrupole technology was optimized to obtain maximum sensitivity. The analysis was performed using Thermo Scientific™ TriPlus™ RSH Liquid Autosampler mounted on a Thermo Scientific™ TSQ™ 8000 Evo GC-MS/MS system. The application note describes the sample preparation technique, set-up of the instruments and the data collections and processing using Thermo Scientific™ Trace Finder™ software. It concludes that the system is an extremely effective tool for the routine analysis of THCCOOH in hair samples.