Sequence analysis of antisense nucleic acid using a MALDI-8030 benchtop MALDI-TOF mass spectrometer

MALDI-ISD fragmentation of nucleic acids provides successive fragment ions by simple cleavages and is a highly useful tool for simple sequencing of nucleic acids. This application note from Shimadzu describes an example of sequencing antisense nucleic acids by ISD fragmentation using a Shimadzu MALDI-8030 benchtop linear MALDI-TOF mass spectrometer.