Shimadzu’s Guide to US EPA Method 537: Determination of Selected Perfluorinated Compounds in Drinking Water Using the Triple Quadrupole LCMS-8060

EPA Method 537 is a solid phase extraction (SPE), liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for selected Perfluorinated Compounds (PFCs) in drinking water. This paper presents an evaluation of the instrumental portion of the method using the Shimadzu LCMS-8060 triple quadrupole mass spectrometer. The LCMS-8060 is Shimadzu’s most sensitive LC-MS/MS. Calibration ranges and estimated detection limits were well below method requirements. In addition, the chromatography was shortened from the 25 minutes in EPA 537 to less than 10 minutes without loss of resolution.