Simplified and fast analysis of per- and polyfluoroalkyl substances in non-potable waters

In this application note, Agilent describes a method for the separation and detection of 28 per- and polyfluoroalkyl substances (PFAS) in water samples. The method uses an Agilent 1290 Infinity II LC coupled to an Agilent 6470A triple quadrupole LC/MS system with Agilent MassHunter workstation software. All the PFASs included in the ASTM 7979 method are analyzed, and the same sample preparation protocol is used. Water samples of 5 mL are diluted with an equal volume of methanol and injected directly for a reporting limit of 10 parts per trillion (ppt, ng/L) or lower for most of the compounds.