Simplified Method Development with the Tecan AC Extraction Plate™

The ideal sample preparation process for further analysis by techniques such as LC-MSMS should be simple, involve relatively few steps, produce a clean sample free from interfering matrix materials and, to increase analytical sensitivity, concentrate the analyte of interest. This technical note describes how to use the AC Extraction Plate as a method development tool for specific analytes for LC-MSMS analysis, by optimizing the three ‘pipette and shake’ steps.