Simultaneous Non-Invasive in vivo Imaging of Apoptosis and Angiogenesis in a Mouse MDA-MB-231 Xenograft Model

In this report, the effects of 3 days of oral treatment on apoptosis and angiogenesis were studied using non-invasive in vivo fluorescence imaging in correlation with immunohistology readouts. GLPG1790 is a small molecule nanomolar inhibitor of ephrin- and a few other tyrosine kinases that shows potent anti-tumor activity in vitro and in vivo in a mouse MDA-MB-231 xenograft model.