Single domain antibody development from ProSci

Single domain antibodies (sdAbs), also known as VHH antibodies, are recombinant antibodies comprised of the binding domain from heavy chain only camelid antibodies. Due to their small size, ~15kDa, and their longer and structurally unique Complementarity Determining Region 3 (CDR3 region), they target unique epitopes inaccessible by conventional antibodies. This application note explores ProSci’s single domain antibody development service that offers two different packages: Premier – Immunization through library construction, and Pro – Immunization through final clones, as well as customized packages. The current catalog of ProSci sdAbs also includes antibodies to select immune checkpoint targets and SARS-CoV-2 spike glycoprotein S1 and S2 domains.