SONAR – Delivering MS/MS Data from a DIA Experiment

SONAR™ is the newest data independent aquisition (DIA) mode from Waters and is complementary to MS. The strength of SONAR is its increased selectivity, which translates to cleaner MS/MS data, allowing both discovery and quantification from a single injection using commonly accepted and established workflows.

SONAR delivers this increased selectivity with rapid scan rates to provide the following analytical benefits:

• All the information required for quantification and identification in a single injection
• Scan rates compatible with UPLC speeds for reliable quantitation
• Library searches are more reliable due to cleaner MS/MS spectra
• Laboratory workflows become more efficient as time consuming method development associated with MS/MS analysis is removed

This white paper discusses in detail the principles and applications of SONAR