Spatial resolution of the tumor and immune cell lineages in the hypoxic microenvironment of pancreatic ductal adenocarcinoma

In this application note, Leica Microsystems explores the significance of understanding the evolution of the tumor microenvironment (TME) and its connection to tumorigenesis. The focus is on the classification of CD45+ cells in different regions, as well as the importance of therapeutic response for personalized cancer treatments. The use of multiplexed imaging technologies is highlighted, which employ immune and oncology biomarker antibodies to analyze immune cell lineages and structures within the TME of various neoplasms.