Spatially Restricted Exposure of Toxins to Neurons and its Impact on Axonal Degeneration Using AXIS™

Due to their size, shape, and function, neurons and their distal axons are continually exposed to differing factors which can mediate neurotoxic effects. Utilizing a novel microfluidic Axonal Isolation System (AXIS™) EMD Millipore was able to spatially isolate axons so they could be directly and specifically exposed to neurotoxins to determine if the neurotoxic effects observed were due to direct axonal exposure or mediated by the neuronal cell body.