Stereoselective Separation of Triazole Fungicides Using the ACQUITY UPC2 System and ACQUITY UPC2 Trefoil Chiral Columns

The development of analytical methods for the separation of chiral compounds is important in many areas of research, as it is well known that different enantiomers are selectively biologically active. It is estimated that 20 to 30% of pesticides on the market today have optical isomers, and there are reports that 40% of the pesticides used in China are chiral. This application note presents the enantiomeric and/or diastereomeric resolutions of 12 triazole fungicides using Waters® Trefoil Column Technology.