Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform

Ion-pairing reversed-phase liquid chromatography (IPRP-LC) has been established as the main chromatographic technique for the analysis of oligonucleotide therapeutics, especially when connected to mass spectrometry. However, chromatographic approaches alone still suffer from an inherent lack of selectivity.

Explore how a streamlined approach using Orbitrap-based LC-HRAM-MS platforms can be a valuable tool for the characterization and monitoring of therapeutic oligonucleotide impurities.