Studying Paneth Cell Differentiation Using the Tecnai with iCorr

Intestinal Paneth cells, originally identified as an anti-microbial secreting cell population, have emerged as critical modulators of active cycling intestinal stem cells, supplying critical molecular cues that influence stem cell behavior. In a study to elucidate factors that influence Paneth cell differentiation, Nick Smith and Melissa Wong (OHSU) used the Tecnai with iCorr to perform correlative light and electron microscopy imaging of mouse intestinal tissue to evaluate the full differentiation of the Paneth cell population.