Target Nano LC-MS Quantification of Rituximab in Human Bio-Matrix with High-Resolution Accurate Mass MS

Nano LC HR MS targeted Selected Ion Monitoring (tSIM) and Parallel Reaction Monitoring (PRM) can be used to develop sensitive and selective methods for quantification of monoclonal antibody (mAb) in complex bio-matrices. This application note shows the development and comparison of tSIM and PRM methods to DDA detection of rituximab.