Targeted Hi-C: Uncovering local genome architecture in regions of interest

Genome-wide conformational studies using Hi-C proximity ligation approaches can be expensive due to the total sequencing burden required. Here, Dovetail Genomics conducts a study in order to better understand whether overall sequencing costs can be reduced by combining targeted enrichment with Omni-C^™ chemistry. Their results demonstrate the use of a hybrid capture panel with the Omni-C^™ Kit on cell lines and cancerous tissues resulting in Omni-C Proximity Ligation libraries enriched for various genes implicated in cancer.