The Benefits of Gas-Phase Collision Cross-Section (CCS) Measurements in High-Resolution, Accurate-Mass UPLC/MS Analyses

This white paper discusses the benefits of gas-phase CCS measurements in HR, accurate-mass UPLC/MS analyses. The rotationally-averaged CCS may be measured experimentally using ion mobility mass spectrometry. CSS is an important distinguishing characteristic of an ion in the gas phase, being related to its chemical structure and three-dimensional conformation. Therefore, it allows the separation of isomers, conformers and promoters and gives increased peak capacity and resolution.