The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability

The ability to screen protein formulations at the early stages of development enables scientists to concentrate on the most suitable candidates and so save substantial amounts of time, sample and testing equipment. This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with the DynaPro Plate Reader II in order to rank the effectiveness of candidates and formulation conditions.