The DNA damage response and innate immunity

Innate immunity and DNA repair are critical sense-response systems that have evolved to protect cells from external and internal threats: tumors, invading pathogens, toxic agents, and physical wounds. Both systems are the focus of intense research and drug discovery activity to enable more effective therapies for cancer and debilitating autoimmune and inflammatory diseases. Interconnections between innate immune responses triggered by nucleic acids and DNA repair pathways have emerged, and they are rapidly being translated into exciting, new therapeutic strategies. In this application note, explore how BellBrook Labs are trying to accelerate these efforts, showing biochemical assays for key enzymes in the innate immunity and DNA damage response (DDR) pathways using the Transcreener® HTS Assay platform.