The Reveleris® Flash Cartridge Can be Used in the Impurity Isolation of Valproic Acid from Cyclodextrin During Encapsulation Overcoming Drug Delivery Challenges

In this application note the separation of valproic acid from its entrapment-carrier, γ-cyclodextrin, has been shown using the Reveleris® flash cartridge with the RevealX™ detection technology. Valproic acid is one of the major antiepileptic drugs, also effective in treating cancer. Although water is usually used as the reaction medium for enzymes, organic solvents or cyclodextrins can be added to improve the solubility of poorly soluble compounds.