The use of adenosine 5’-triphosphate (γ-P18O4, 97%) for the unambiguous identification of phosphopeptides

Phosphorylation is arguably the key signaling event that occurs within cells controlling processes such as metabolism, growth, proliferation, motility, differentiation, and division. Determining kinase specificity has long been a key research area in molecular biology and is important to a variety of fields, including cancer research, cell and developmental biology, and drug discovery.

In this application note, Cambridge Isotope Laboratories describes a stable isotope-labeling approach that provides unambiguous identification of phosphorylated peptides produced through in vitro kinase reactions