The Use of Elplasia™ Microplates for Antibody-Dependent Cell Mediated Cytotoxicity (ADCC) Applications

The need for biologically relevant assays with clinical translatability has brought the 3D cell culture model to the forefront of drug discovery. Traditional pharmacological studies done in cell monolayers have limited translational value; because, they do not capture the known complexity of the tumor microenvironment that is found to modulate drug sensitivity and resistance. In this application note, the suitability of Kuraray's Elplasia Square Type plates for antibody-dependent cell mediated cytotoxicity assays, using 3D cell culture, is tested.