TOC Determination in Cleaning Validation – Final Rinse

The highest purity and most careful handling of substances and active ingredients is an important requirement in the manufacture of pharmaceuticals. An effective removal of production residues in pharmaceutical plants is an essential precondition. A well-cleaned pharmaceutical production system prevents contamination and, consequently, the adulteration of the produced drug. This is particularly important in the production of active ingredients in batch processes, as the system is used for different products and contamination of the next product must be prevented. This application note explains the determination of the TOC in validating the cleaning process.