Transcreener® High Throughput Screening Assays for Glycosyltransferases

Identifying glycosyltransferase inhibitors remains a challenging task in drug discovery, because for many enzymes in this diverse class, screening methods have been limited to expensive and cumbersome radiolabeled assays or HPLC/MS analyses. As shown here, over the last few years Transcreener® glyscosyltransferase assays have been developed based on the simple and direct immunodetection of nucleotides, which are easily adaptable to automation and systemized high throughput screening protocols.