Ultra-Fast Forensic Toxicological Screening and Quantitation under 3 Minutes using SCIEX X500R QTOF System and SCIEX OS 1.0 Software

There has been increasing use of high resolution and accurate mass LC-MS/MS systems for drug screening in forensic toxicological settings. This technical note, presents an ultra-fast forensic toxicological screening method using the new SCIEX X500R QTOF system and SCIEX OS 1.0 software. The LC runtime of this method is 2.5 minutes. Two different non-targeted data acquisition methods were used and compared, both of which yielded data that can be analyzed retrospectively.