ResourceSpectroscopy

Uncover new dimensions of isotope ratio analysis with Thermo Scientific Orbitrap MS technology

6 Jun 2025

Isotope ratio mass spectrometry (IRMS) is a powerful tool for determining subtle isotopic variations within a sample and works by breaking down complex molecules in simple gases. This technique can provide unique insights however important intramolecular isotopic information is often lost.

Explore a new, comprehensive approach to IRMS using electrospray ionization (ESI). Thermo Scientific™ Orbitrap™ MS technology gives access to a wide range of isotopic information from a variety of polar compounds in liquid samples. In contrast to classical IRMS methods, Thermo Scientific™ Orbitrap Exploris™ Isotope Solutions enable the calculation of isotope ratios directly from the relative abundances of the compounds isotopologues, measured as intact molecular ions.

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