Universal method for quantification of multiple oligonucleotides by MFLC-MS/MS

Bioanalysis of oligonucleotides by HPLC-MS/MS in support of regulatory submission has not been widely adopted. Several obstacles such as lack of sensitivity, adduct formation and analytical instrument dedication are barriers that many laboratories are unwilling to challenge. In this application note from Alturas Analytics, learn more about how microflow HPLC can be used to increase the sensitivity of the method, and thus reduce adduct formation.