Use of high-resolution ion mobility for PFAS isomer separation

Due to growing concern over their toxicological significance, analytical methods for PFAS (Per- and Polyfluoroalkyl Substance) are continuing to evolve. Targeted methods have historically been utilized with liquid chromatography and tandem mass spectrometry (MS/MS) the predominate combination used. In this application note, MOBILion Systems demonstrates the combination of liquid chromatography (LC), high-resolution ion mobility (HRIM), and high-resolution mass spectrometry (HRMS) for PFAS analysis.