Use of Multiple Assay Platforms to Investigate the p53-MDM2 Interaction and its Influence on p53 Ubiquitination

Robust, scalable, and biologically-informative assays for ubiquitin processes have the potential to reveal new biology for therapeutic exploitation. In this poster learn how such tools can be used to examine two distinct steps – E3-substrate binding and ubiquitin ligation – in the well studied MDM2-p53 system.