Using Bio-Plex Phosphoprotein Assays to Study EGFR Signaling in Human Patient-Derived Xenografts Treated with Cetuximab

Cetuximab has been used to treat many advanced cancers, but is only effective in a fraction of patients. In this application note by Bio-Rad the Bio-Plex phosphoprotein assays were used to demonstrate that the effectiveness of cetuximab is not determined solely by its ability to inhibit EGFR activation.