Utility of Desorption Electrospray Ionization (DESI) for Mass Spectrometry Imaging

DESI imaging uses a charged jet of solvent to deposit micro-droplets onto a surface where analytes are extracted and desorbed into the gas phase at ambient pressure and temperature. This application note describes the DESI imaging technique as applied to mass spectrometry imaging using time-of-flight (TOF) mass spectrometers, such as the SYNAPT® G2-Si or the Xevo® G2-XS.