Utilization of Immunoglobulin Free Light Chains as a Biomarker of B Cell Dysregulation in HIV Patients: Quantitation Using a New Rapid Test (Seralite®)

HIV-infected individuals have B cell dysregulation which contributes to immunodeficiency and risk of AIDS progression and B cell Non-Hodgkins Lymphoma. B cell dysregulation is characterized by an increased production of intact immunoglobulins (e.g. IgA, IgM, IgG) and free light chains (FLC). FLCs are regarded as a more sensitive marker of B cell activation status. This poster describes a study to assess the clinical utility of measuring FLC levels in HIV-infected individuals using a new and cost-effective rapid lateral-flow test that quantitates serum FLC in 10 minutes.