Validation of a Multiple Compound Addition Assay for hERG ion channel on the IonWorks Barracuda™ Automated Patch Clamp System

In this study, a multiple compound addition assay for hERG channel was validated by Molecular Devices. Compared to previously reported cross-plate assay, this “within-well” method examines cumulative concentration-response in a similar manner to manual patch clamp, with unparalleled throughput (4,6000 data points/hour) and comparable pharmacology...