Validation of the IonWorks Barracuda System for hERG Ion Channel Assay

Drug-induced inhibition of the hERG ion channel has been implicated in the susceptibility of patients to potentially fatal ventricular tachyarrhythmia, torsade de pointes. In 2005, Shawn Handran et al. published a hERG pharmacological assay using the IonWorks Quattro System. This application note investigates whether the assay can be easily transferred to the IonWorks Barracuda System, while producing the same pharmacological results.