When to Use Targeted Resequencing — Choosing the Right NGS Method

With such proliferation of next generation sequencing (NGS) technologies and methods, it may not always be immediately obvious which approach is the most suitable for a given study. While whole genome sequencing (WGS) provides the most comprehensive data, it is not a cost-effective technique for identifying rare variants such as those found in heterogeneous cancer samples. It also generates high volumes of data, which makes analysis particularly complex and resource-intensive. This whitepaper aims to examine the various targeted resequencing strategies available and explore when they are appropriate, in order to aid investigators in choosing the most suitable NGS method.