Immune humanized mouse platforms for pre-clinical applications

The highly immunodeficient NSG™ platform enables precise in vivo modeling of human immune responses, providing researchers with a powerful tool for characterizing and validating immune-modulating therapeutics. Dr. Charu Gupta, technical information scientist from the Jackson Laboratory, compares strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research. Learn about techniques for humanizing immune cells using the NSG platform, the effects of host selection and genetic modifications on immune phenotypes, and novel NSG variants enhancing human innate immune cell development.