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LC troubleshooting - All of my peaks are tailing! What should I do?

27 Apr 2021
LC troubleshooting - All of my peaks are tailing! What should I do?

Tailing peaks can be a problem when doing liquid chromatography (LC), and secondary silanol interactions are one of the causes. Here, using the example of basic drugs, Restek explains what causes them and cover a few steps that can be taken to minimize the effect of these secondary silanols on peak shape when troubleshooting.

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