A systems-level approach to understanding the immunology of COVID-19 in adults and children
This webinar will present recent studies from Dr. Petter Brodin's group at Karolinska Institute in Stockholm that provide important new insights into the immune system responses to SARS-CoV-2 infection. These studies took a systems-level approach to analyze both the cellular and protein components involved, using methodologies including mass cytometry, flow cytometry and high-multiplex proteomics.
A longitudinal study of severe COVID-19 patients identified distinct patterns of immune cell coregulation in four different stages of the disease and demonstrated a shared trajectory of immunological recovery that may provide future biomarkers of disease progression. In an investigation of Multisystem Inflammatory Syndrome in Children (MIS-C), a relatively rare complication of SARS-CoV-2 infection in children, important differences in inflammatory response were seen between MIS-C and severe COVID-19 in adults. Moreover, while some similarities were observed between inflammatory responses in MIS-C and Kawasaki disease, important differences were also apparent, particularly in the T-cell subsets involved.
Key Learning Objectives
- Observe how a systems-level approach combining multiple methodologies can provide essential insights into complex biological questions such as immune responses
- See the impact of combining cellular and molecular analyses in trying to better understand the intricate and varied immune system responses in COVID-19
- Learn how protein biomarkers can contribute to a deeper understanding of the pathophysiology of COVID-19 and facilitate future treatment strategies
Who Should Attend
- Molecular or cell biologists, clinicians or scientists in the pharmaceutical industry who have an interest in COVID-19, or more broadly in the human immune system
Certificate of attendance
All webinar participants can download a certificate of attendance for continuing education purposes from the webinar auditorium’s resources section.