Advancements in 3D modeling: Building mature, functional 3D skeletal muscle microtissues in vitro

In this webinar, Dr. Marieke Aarts from Bi/ond and Amanda Turner from bit.bio will explain how Bi/ond has successfully cultured bit.bio’s human iPSC-derived ioSkeletal Myocytes™ on the perfusable organ-on-chip platform, generating 3D skeletal muscle microtissues.

They will also examine how functional 3D muscle bundles containing striated multinucleated myocytes can be reliably generated in less than a week. In addition, they will discuss how to pace and train muscle tissue simulating physiological conditions, and how to achieve accelerated muscle maturation and enhanced contractile response. Finally, they will share how Bi/ond’s chip technology can assist with the study of vascularization, dynamic drug response, and even mimic the immune system's response.

Key learning objectives

• Discover how to culture 3D muscle cell bundles on Bi/ond's MUSbit™ platform.
• Learn how to combine Bi/ond's technology with ioSkeletal Myocytes for measuring muscle contractions triggered by electrical stimulation
• Explore the translational potential of the MUSbit/Let-it-bit™ for pharmacological studies on wild-type and disease model cells

Who should attend?

• Everyone interested in culturing 3D muscle tissues on a chip
• Researchers developing translational models for muscle disease
• Researchers looking for a robust in vitro model for muscle contraction

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.