An ACD Spatial Biology Symposium: Diversity, development, and dysfunction in the brain: using a multi-omic approach to neuroscience research

The rapidly emerging field of spatial biology research utilizes a multi-omic approach to characterizing the transcriptomic profiles heterogeneous organs and tissues, including the mammalian brain and associated tumors. RNAscope™ in situ hybridization (ISH) assays enable visualization of single RNA molecules at the single-cell level whilst maintaining the tissue microenvironment and spatial context.

In this Spatial Biology Symposium, we will highlight the innovative research of three neuroscientists who leverage multi-omic technologies to provide insight to complex pathways and disease models

Session 1: 17:00 BST / 18:00 CEST / 09:00 PDT / 12:00 EDT

Title: Molecular characterization of retinal ganglion cell subtypes in the human retina

Learning objectives:

Understand how human RGC subtypes can be defined by the combinatorial expression of dozens of genes

Learn how RNAscope HiPlex permits the identification of many of these subtypes in a single experiment

Discover how human retinal organoids generate multiple RGC subtypes

Session 2: 18:15 BST / 19:15 CEST / 10:15 PDT / 13:15 EDT

Title: Mechanisms regulating homeostatic sleep pressure: The heterogeneity of hypothalamic Lhx6 neurons and their role in sleep

Learning objectives:

Understand that hypothalamic Lhx6 neurons are a heterogenous GABAergic population

Learn how Calb1, Cck, Gal, and Nfia define molecularly distinct subtypes of Lhx6 neurons

Discover how increased Fos activation is induced by elevated sleep pressure and persists even after several hours of recovery sleep

Session 3: 19:15 BST / 20:15 CEST / 11:15 PDT / 14:15 EDT

Title: Anterior thalamic dysfunction underlies cognitive deficits in psychiatric disease models

Learning objectives:

Explore the role of the thalamus in cognition

Understand the converging mechanisms underlying cognitive deficits in different disease models

Discover how to rescue cognition by targeting thalamocortical

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