Enhanced Single-Cell DNA Methylation Analysis Using Highly Parallelized Barcoding Coupled with Nuclei Sorting

The epigenetic landscape of the human brain undergoes transformations during development, when DNA methylation plays a crucial role. While traditional bulk techniques lack the precision of single-cell approaches, the latter have been constrained by high costs and labor intensity.

In this webinar, Dr. Sanika Khare, an application scientist at Scale Biosciences, will discuss how Scale Bioscience's innovative combinatorial indexing technology, coupled with Sony’s SH800 Cell Sorter, revolutionizes single-cell DNA methylation analysis with a cost-effective and efficient plate-based workflow, providing high-throughput capabilities. She will explain how this approach ensures high recovery rates, robust cytosine coverage, and the identification of cell-type-specific clusters during various developmental stages. Compared to bulk profiles, it reveals distinct single-cell methylation patterns, offering unparalleled insights into developmental methylation alterations and cellular heterogeneity.

Key learning objectives

• Explore how Scale Bioscience's combinatorial indexing technology, coupled with Sony’s SH800 Cell Sorter offers precise and efficient single-cell DNA methylation analysis
• Learn how the SH800 Cell Sorter improves the outcomes of single-cell methylation studies
• Discover insights into developmental methylation alterations and cellular heterogeneity

Who should attend?

• Epigenetics researchers or specialists focusing on DNA methylation dynamics during brain development
• Biotech and genomics professionals interested in enhanced DNA methylation site pinpointing
• Lab technicians and methodologists seeking to streamline their workflows for single-cell DNA methylation analysis

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.