Advanced mRNA and LNP Strategies for CRISPR Delivery

Delve into exciting new technologies pushing the boundaries in research and advancing the development of novel therapeutics. Through a series of engaging presentations by experts in the fields of synthetic peptide technologies, genome editing, and drug development, our speakers will dive into the latest advances and trends in neoantigen peptide discovery for personalized cancer immunotherapy, the promising potential of mRNA-based tools for gene editing, and the innovative world of self-amplifying RNAs as a cutting-edge modality, shaping the next generation of RNA vaccines.

Recent breakthroughs in RNA therapeutics have unveiled the incredible potential of mRNA-based tools for gene editing. Lipid nanoparticles (LNPs) can co-encapsulate mRNA and guide RNA for highly efficient delivery both to cells in vitro and in vivo.

GenScript’s cutting-edge platform produces top-quality mRNA with enhanced expression, reduced immunogenicity, and extended half-life. Paired with a novel guide RNA design, this guarantees exceptional editing efficiency with low off-target effects.

In this webinar, Dr. Shambhavi Shubham, field application scientist at GenScript will share how the company harnesses advanced formulations of CRISPR enzymes like Cas9 and Cas12, and Prime editing to achieve powerful gene editing. To further elevate performance, GenScript leverages advanced strategies, including customizing CRISPR mRNAs with tissue-specific UTRs, optimizing IVT conditions to reduce dsRNA, and using codon optimization and circular RNA forms. Moreover, to meet precise delivery needs, GenScript technology leverages antibody-decorated or SORT LNPs.

Join us and learn how GenScript’s advanced platform serves the needs of researchers and biopharmaceutical companies by driving the rapid development of ground-breaking therapeutics and propelling genetics research forward.

Key learning objectives

• Understand the mechanisms and potential of mRNA-based tools for gene editing
• Discover the use of lipid nanoparticles (LNPs) for co-encapsulating mRNA and guide RNA, facilitating efficient delivery in vitro and ex vivo
• Gain insights into advanced formulations incorporating CRISPR mRNA like Cas9 and Cas12, as well as prime editing
• Explore strategies for achieving targeted delivery through antibody-decorated LNPs or SORT LNPs to increase efficiency at specific sites

Who should attend?

Audiences working on mRNA, gene editing, and LNP delivery solutions

Interested in this webinar? Explore the other webinars in this series on Applications and Challenges of Neoantigen Peptides in Personalized Cancer Vaccines and Self-Amplifying RNA in Vaccines and Beyond

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes