Simplify volatiles analysis (Part 3): Method development and validation for direct MS

Method validation is critical to adoption of an analytical method, but how does one tackle it for direct mass spectrometry (DMS) techniques? In this webinar (the third in a four-part series), we answer this question in the context of selected ion flow tube mass spectrometry (SIFT-MS), the leading automated DMS technique for analysis of volatile compounds.

First, we will make a comparison of method development for SIFT-MS and conventional chromatographic techniques. Then, using a detailed case study on headspace analysis of volatiles in water, we will describe how to develop and validate a SIFT-MS method so that the data can be used to support regulatory requirements. This is achieved by applying a strategic approach in accordance with ICH Q2(R1) Guidelines. Finally, a second brief case study describes analysis of BTEX in soil following methanolic extraction. Note that a third case study – analysis of residual formaldehyde analysis in novel drug delivery devices – will be described in the final webinar in the series. The case studies demonstrate the efficient method development and validation (and high sample throughput) achievable using automated SIFT-MS.

Join us for this webinar to learn more about how SIFT-MS works, how it speeds up analysis, and how it can be validated successfully in accordance with ICH Q2(R1) Guidelines suitable for pharmaceutical applications such as regulatory submissions where GMP compliance is essential.

Key Learning Objectives:

• Very brief review of SIFT-MS and its automation Method development: similarities and differences between SIFT-MS and conventional chromatographic techniques
• How to apply the ICH method validation parameters to SIFT-MS
• Two case studies of method development and validation with SIFT-MS: soil analysis and water analysis

Who should attend:

• Laboratory managers and analysts in routine industrial and contract testing and research laboratories, particularly those working with the analysis of volatiles
• Laboratory managers and analysts in pharmaceutical, biomedical, industrial, consumer product, and environmental laboratories

Certificate of attendance

All webinar participants can request a certificate of attendance and a learning outcomes summary document for continuing education purposes.