The spatial and functional heterogeneity of PDAC tumor sub-populations

Pancreatic cancer is therapeutically resistant and metastatic. It is defined by a vast, heterogeneous microenvironment, and two distinct, but metastatic, cancer cell populations. Using genetic mouse models, we have begun unraveling the complex functions and interactions of these tumor sub-populations. In this webinar, Dr. Julienne Carstens, Assistant Professor at the University of Alabama at Birmingham, will discuss the findings of the tumor regulatory properties of microenvironmental sub-populations, and their function-location linkage within the tumor.

The presentation will focus on Dr. Carstens's work which highlights the role of T cells in regulating tumor outcomes that were primarily appreciated within their spatial context. Finally, Dr. Carstens will discuss ongoing efforts to expand upon these observations and define functional networks comprised of intracellular signalling and environmental factors.

Key learning objectives

• Understand how the Lunaphore COMET^™ performs automated hyperplex immunofluorescence on mouse formalin-fixed paraffin-embedded (FFPE) samples.
• Learn how spatial hyperplex immunofluorescence with the Lunaphore COMET^™ can support the identification of different tumor sub-populations
• Discover how Visiopharm®-based image analysis can help identify functional cell populations.
• Explore the latest findings in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC).

Who should attend?

• Scientists interested in immuno-oncology, oncology, and immunology.
• Researchers interested in using automated multiplex immunofluorescence solutions on mouse and human samples.

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.