Unlock complex cell-based binding and avidity dynamics
Feb 27, 2025 – 15:00 GMT / 16:00 CET / 10:00 EST / 7:00 PST
Join Dr. Nichole Cerutti, Director of Biophysics at RoukenBio, and Dr. Vivien Hafner, Head of Scientific Communication and Marketing at Bruker Biosensors to unlock the power within single-cell interaction cytometry, and its key role in the development of therapeutics.
These industry experts will showcase the innovative IndEx-2 system created to enable control of titratable protein expression levels. Learn how the combination of the IndEx-2 system and single-cell interaction cytometry can enhance the understanding of therapeutic interactions and efficacy at the cellular level, in the context of different levels of target protein expression.
Key learning objectives
- Understand how different levels of target expression can affect the key characteristics of targeted therapeutics with the IndEx-2 platform
- Discover single-cell interaction cytometry and how it can be used to characterize the kinetics of therapeutic molecules in a more physiologically relevant setting e.g. when binding to their targets on the cell surface
- Explore how the implementation of inducible cell lines with this technology can aid understanding of the binding capabilities of targeted therapeutics
- Learn how target density can influence the kinetics and avidity of molecule binding
Who should attend?
- Translational researchers working in drug discovery and development who are interested in biotherapeutic molecule development, particularly in the areas of oncology, immuno-oncology, auto-immunity, allergy and inflammatory diseases.
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
Speakers
Nichole Cerutti has a PhD in Protein Biochemistry/Molecular Medicine from the University of the Witwatersrand, South Africa and joined RoukenBio in 2021. Training as a protein biochemist in a biophysics-focused laboratory laid the foundation for her subsequent research in HIV drug discovery and vaccine design. Nichole thrives when exploring the ways biophysical methods can be used to answer vital questions around the functioning of therapeutic molecules and their targets, and how this information is used to develop therapeutics. Understanding the structural and functional complexities of proteins and how they can be manipulated and applied in human disease, from treatment through to diagnostics, has always been her career focus. She has published several peer-reviewed publications and has accumulated over 16 years of experience. Nichole leads the research and development of novel biophysical assays using SPR, guides the direction of future biophysics offerings and works closely with the Sales and Operations teams as a technical expert.
Vivien studied Molecular Medicine and did her PhD in the field of haematology and immunometabolism with a focus on cellular therapies for graft-versus-host disease. After completing her academic research, Vivien shifted her focus to scientific communication, where she currently uses her expertise to translate complex scientific concepts into understandable and engaging content.
Moderator
