Viral and non-viral vectors for safe and efficacious gene delivery

Non-viral vectors transform gene delivery for cell therapies

Cell and gene therapies are set to become a new standard of healthcare but are complex and difficult to manufacture at scale. This has prompted technology providers to develop new approaches – including the exploration of non-viral vectors for gene delivery – that tackle long-standing challenges and help to move therapies forward from the bench to the bedside. In this article, we review the advantages of non-viral vectors over viral gene delivery systems. In particular, we explore a novel and exciting non-viral system using transposons: TcBuster from Bio-Techne.

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Stem cells deliver next-gen targeted immunotherapies

Calidi Biotherapeutics is developing the next generation of targeted immunotherapies using the combination of stem cells with oncolytic viruses. In this video, Dr. Antonio F. Santidrian, PharmD,  Ph.D., Chief Scientific Officer at Calidi Biotherapeutics, describes how this unique tumor-agnostic technology protects the virus against the immune system, allowing the therapy to have an immediate and powerful effect on the target tumor. Learn about products in development for high-grade glioma, advanced solid tumors and metastatic solid tumors, and Santidrian’s thoughts on the future of immunotherapy.

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​Dr. Krishanu Saha
​Dr. Krishanu Saha
Innovation helps unlock gene therapy delivery success

The successful application of gene therapy relies heavily on efficient and targeted delivery mechanisms. Overcoming current gene therapy delivery challenges is crucial to unlocking its full potential and bringing about transformative advancements in medicine. In this article, learn more about how lipid nanoparticles and innovations with viral vectors are forming part of the solution to these challenges.

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The latest advances in cell and gene therapy research

Explore the latest developments in cell and gene therapy with fellow scientists, manufacturers, and regulatory experts.

The cell and gene therapy products reviewed by you

NovoCyte Flow Cytometer by Agilent Technologies

"A top value machine and lifesaver of pre/post services" - Lei Zhang, CytoImmune Therapeutics

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Jess™ by Bio-Techne

"Would recommend this product to others looking for high throughput Western Blots" - Mark Sochaski, AgBiome

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ÄKTA pure protein purification system by Cytiva

"Great results and a workhorse - could imagine life without this instrument!" - Carlos Rosado, Monash University

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