Non-viral vectors transform gene delivery for cell therapies
Cell and gene therapies are set to become a new standard of healthcare but are complex
and difficult to manufacture at scale. This has prompted technology providers to develop new approaches –
including the exploration of non-viral vectors for gene delivery – that tackle long-standing challenges and
help to move therapies forward from the bench to the bedside. In this article, we review the advantages of
non-viral vectors over viral gene delivery systems. In particular, we explore a novel and exciting non-viral
system using transposons: TcBuster from Bio-Techne.
Stem cells deliver next-gen targeted immunotherapies
Calidi Biotherapeutics is developing the next generation of targeted
immunotherapies using the combination of stem cells with oncolytic viruses. In this video, Dr. Antonio F.
Santidrian, PharmD, Ph.D., Chief Scientific Officer at Calidi Biotherapeutics, describes how this unique
tumor-agnostic technology protects the virus against the immune system, allowing the therapy to have an
immediate and powerful effect on the target tumor. Learn about products in development for high-grade
glioma, advanced solid tumors and metastatic solid tumors, and Santidrian’s thoughts on the future of
immunotherapy.
Innovation helps unlock gene therapy delivery success
The successful application of gene therapy relies heavily on efficient and
targeted delivery mechanisms. Overcoming current gene therapy delivery challenges is crucial to unlocking
its full potential and bringing about transformative advancements in medicine. In this article, learn more
about how lipid nanoparticles and innovations with viral vectors are forming part of the solution to these
challenges.
Explore the latest developments in cell and gene therapy with fellow scientists,
manufacturers, and regulatory experts.
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