Product & ReviewsAntibodies
3-Methylcytosine (3-mC) rabbit antibody (pAb), sample
Product Details
- Cat. No.
- 61112
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Methylation of DNA can occur non-enzymatically at the nitrogen-three of the cytosine base through spontaneous exposure to endogenous S-adenosyl methionine (SAM). The resulting 3-methylcytosine (3-mC) is mutagenic and must be reaired, which occurs in humans through the base excision repair (BER) or dealkylation via human homologues of the E. coli AlkB protein. 3-methylcytosine is present in human cell lines and increased levels of 3-mC impair proliferation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Not Species Specific, Human, Mouse
- Isotype: IgG
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Dot Blot (DB)