5-lipoxygenase Antibody
Product Details
- Cat. No.
- 251179
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and plays a role in inflammatory processes. 5-lipoxygenase is expressed specifically in bone marrow-derived cells. This enzyme catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(s)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma. These mutations are also associated with atherosclerosis and several cancers.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human 5-lipoxygenase.
- Isotype: Rabbit Ig
- Gene: P09917
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)