5-Methylcytosine (5-mC) mouse antibody (mAb) (Clone A1), sample
Product Details
- Cat. No.
- 61480
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
5-Methylcytosine (5-mC) is a modified base that is found in the DNA of plants and vertebrates. DNA methylation is an epigenetic event in which DNA methyltransferases (DNMTs) catalyze the reaction of a methyl group to the fifth carbon of cytosine in a CpG dinucleotide. This modification helps to control gene expression and is also involved in genomic imprinting, while aberrant DNA methylation is often associated with disease. The 5-methylcytidine antibody (Clone A1) has been developed to discriminate between the modified base and its normal cytosine counterpart, allowing for gene promoter methylation analysis.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Not Species Specific
- Clone: A1
- Isotype: IgG1
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Dot Blot (DB)
- Methylated DNA Immunoprecipitation (MeDIP)